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. 2016 Jul 25;6:30207. doi: 10.1038/srep30207

Figure 4. The enhanced directionality of mDC-MDA-MB-231 toward CCL19 is significantly decreased by the inhibition of JNK activity.

Figure 4

(a) The expressions of JNK and c-Jun molecules in mDC only or mDC-MDA-MB-231 in the presence or absence of a 30 μM JNK inhibitor (SP600125) with or without CCL19 treatment. (b,c) Data represent mean ± s.e.m. of the ratio of p-JNK/T-JNK or p-c-Jun/T-c-Jun from three independent experiments described in (a). Uncropped western blot images are shown in Supplementary Fig. S8b. p = phosphorylated, T = total. (d,e) Box-and-whisker plots of the velocity (d) and directional persistence (e) of mDC only or mDC-MDA-MB-231 treated with various concentrations (0, 30 or 100 μM) of SP600125. n ≥ 40. *P < 0.05, **P < 0.01 and ***P < 0.001.