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. 2016 Jul 25;6:30301. doi: 10.1038/srep30301

Figure 4. Effects of CoQ10 on NAD (P) H oxidase subunit NOX2 and NOX4 (membrane- associated oxidase proteins) in the PVN of high salt-induced hypertensive rats by immunohistochemical and immunofluorescence staining.

Figure 4

Results showed that HS rats had stronger fluorescence intensity of NOX2 and NOX4 compared with NS rats (P < 0.05, n = 7). 15-week of CoQ10 administration by gavage at the dose of 10 mg/kg/day significantly decreased NOX2 and NOX4 expression (P < 0.05, n = 7). (A) A representative immunohistochemical staining of NOX2 and a representative immunofluorescence staining of NOX4. (B) Densitometric analysis of immunofluorescent intensity of NOX2 in the PVN in different groups. (C) Densitometric analysis of immunofluorescent intensity of NOX4 in the PVN in different groups. Values are expressed as means ± SE. *P < 0.05 vs control (NS + oil or NS + CoQ10), †P < 0.05, HS + CoQ10 vs HS + oil.