Table 1. The enriched biological pathways.
| Database | Term | Cold-Dry | Hot-Wet | ||
|---|---|---|---|---|---|
| KEGG | Frequency | P-value | Frequency | P-value | |
| Antigen processing and presentation | 9% | 3.68E-03 | 13% | 1.39E-03 | |
| Dilated cardiomyopathy | 7% | 5.72E-03 | |||
| ECM-receptor interaction | 9% | 2.08E-02 | |||
| Endocytosis | 10% | 1.38E-03 | |||
| Focal adhesion | 17% | 1.21E-07 | 9% | 1.26E-02 | |
| Gap junction | 10% | 1.27E-05 | 9% | 2.20E-02 | |
| Hematopoietic cell lineage | 9% | 2.70E-02 | |||
| Hypertrophic cardiomyopathy (HCM) | 7% | 4.08E-03 | |||
| Leukocyte transendothelial migration | 9% | 6.30E-04 | |||
| Malaria | 9% | 7.87E-03 | |||
| Pathogenic E. coli infection | 13% | 6.04E-11 | |||
| Phagosome | 14% | 6.08E-06 | |||
| Regulation of actin cytoskeleton | 17% | 3.84E-08 | |||
| Tight junction | 15% | 6.88E-09 | |||
| Vascular smooth muscle contraction | 9% | 3.24E-02 | |||
| Viral myocarditis | 13% | 1.22E-08 | |||
| PANTHER | |||||
| Blood coagulation | 8% | 1.03E-04 | |||
| Cytoskeletal regulation by Rho GTPase | 16% | 8.94E-11 | 17% | 9.94E-04 | |
| Hedgehog signaling pathway | 5% | 2.52E-03 | |||
| Integrin signaling pathway | 12% | 7.70E-04 | |||
| Nicotinic acetylcholine receptor signaling pathway | 9% | 1.85E-04 | |||
| Parkinson disease | 9% | 4.98E-04 | |||
| REACTOME | |||||
| Hemostasis | 24% | 2.67E-13 | 22% | 2.13E-03 | |
| Integrin cell surface interactions | 7% | 4.33E-03 | |||
| Metabolism of proteins | 11% | 2.06E-03 | |||
| Muscle contraction | 4% | 8.01E-03 | |||
The statistically significant enriched pathways are listed based on KEGG, Panther and Reactome databases in each temperament. Some of them are presented in both temperaments with different frequencies.