TABLE 1.
Clinical Characteristics
| All-cause Death or Retransplantation
|
||||
|---|---|---|---|---|
| Variables | All (n = 105) | Present (n = 20) | Absent (n = 85) | p Value |
| Recipient profile | ||||
|
| ||||
| Age, yrs | 52 (42–60) | 45 (20–56) | 53 (43–61) | 0.015 |
| Male | 68.6 | 60.0 | 70.6 | 0.37 |
| Body mass index, kg/m2 | 25.2 (22.6–29.0) | 26.4 (22.0–30.5) | 25.0 (22.6–27.7) | 0.24 |
| Cytomegalovirus IgG positive | 67.6 | 65.0 | 68.2 | 0.78 |
| Diabetes mellitus | 14.3 | 20.0 | 12.9 | 0.43 |
| Hypertension | 36.2 | 10.0 | 42.4 | 0.003 |
| Hyperlipidemia | 27.6 | 15.0 | 30.6 | 0.14 |
| Ischemic cardiomyopathy | 23.8 | 20.0 | 24.7 | 0.65 |
| Statins at 1 year | 93.3 | 95.0 | 92.9 | 0.73 |
| Antidiabetic medications* at 1 year | 30.5 | 35.0 | 29.4 | 0.63 |
| Insulin at 1 year | 21.9 | 30.0 | 20.0 | 0.34 |
| Total cholesterol at 1 year, mg/dl | 169 (149–190) | 163 (152–222) | 171 (145–190) | 0.63 |
| Triglycerides at 1 year, mg/dl | 114 (85–177) | 152 (111–187) | 105 (81–167) | 0.06 |
| LVEF at 1 year, % | 61.0 (57.0–65.0) | 60.0 (54.4–66.1) | 61.0 (58.0–64.5) | 0.58 |
| Acute cellular rejection ≥2R† | 26.7 | 55.0 | 20.0 | 0.002 |
| pAMR ≥2† | 1.0 | 0 | 1.2 | 0.51 |
| De novo DSA | 9.5 | 10.0 | 9.4 | 0.94 |
| Severe rejection‡ | 4.8 | 5.0 | 4.7 | 0.96 |
| Immunosuppressive regimen§ | ||||
| rATG | 37.1 | 5.0 | 44.7 | 0.0002 |
| Tacrolimus | 50.5 | 10.0 | 60.0 | <0.0001 |
| Sirolimus | 13.3 | 35.0 | 8.2 | 0.004 |
|
| ||||
| Donor profile | ||||
|
| ||||
| Age, yrs | 25 (20–40) | 29 (21–44) | 24 (19–40) | 0.18 |
| Male | 73.3 | 60.0 | 76.5 | 0.15 |
| Donor-recipient sex mismatch | 21.9 | 10.0 | 24.7 | 0.13 |
| Cold ischemic time, min | 221 ± 49 | 221 ± 31 | 222 ± 53 | 0.96 |
Values are median (IQR), %, or mean ± SD.
*
Oral antidiabetic drugs and/or insulin.
†
1 or more episodes of grade ≥2R or 2 during the first year post-transplant.
‡
Severe rejection with hemodynamic compromise, defined as a decrease in relative LVEF >25%.
§
Primarily used during the first year post-transplant.
ASP = attenuated-signal plaque; DSA = donor-specific antibodies (during the first year); IgG = immunoglobulin G; IQR = interquartile range; LVEF = left ventricular ejection fraction; pAMR = pathologic antibody-mediated rejection; rATG = rabbit antithymocyte globulin.