Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 21;39(7):543–549. doi: 10.14348/molcells.2016.0050

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Korean Society for Molecular and Cellular Biology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.

PMC Copyright notice

Fig. 4. — APP overexpression reverses the effects of miR-144-3p overexpression on mitochondrial functions. APP was overexpressed after pCMV-APP transfection at mRNA (A) and protein (B) levels. (C) Quantitative analysis of Western strips confirmed the significantly increased expression of APP. (D) APP overexpression significantly decreased ATP level; APP overexpression also significantly reversed the miR-144-3p overexpression-induced ATP level under MPTP conditions. Similar results in cell viability indicated by MTT (E) and the relative copy number of mtDNA (F). The expression of PGC-1α (G), NRF-1 (H) and TFAM (I) was markedly suppressed by APP overexpression in the presence and absence of miR-144-3p overexpression. Each experiment was performed in triplicate. ^* and # represent p < 0.05; ^** and ## represent p < 0.01; n.s. means no statistical significance.