TABLE 1.

Web-based resources for exploring NR signaling pathways

Resource			Name	URL	Reference
Ligands	Physicochemical properties; biosynthesis, transport, and catabolism		PubChem	pubchem.ncbi.nlm.nih.gov	(Kim et al., 2016)
			DrugBank	drugbank.ca	(Law et al., 2014)
			KEGG	genome.jp	(Kanehisa et al., 2014)
			HMDB	hmdb.ca	(Wishart et al., 2013)
	Ligand pharmacogenomics		PharmGKB	pharmgkb.org	(Whirl-Carrillo et al., 2012)
	NRs and ligands	Mappings Probes	IUPHAR GtoP	guidetopharmacology.org	(Southan et al., 2016)
			NIH Molecular Libraries	http://mli.nih.gov/mli	(Schreiber et al., 2015)
NRs and CoRs	Genes, transcripts, and proteins		NCBI Entrez Gene	gene.ncbi.nlm.nih.gov	(NCBI Resource Coordinators, 2016)
			Ensembl	ensembl.org	(Hubbard et al., 2002)
			UniProt	uniprot.org	(UniProt Consortium, 2014)
			GeneCards	genecards.org	(Safran et al., 2010)
	Expression		BioGPS	biogps.org	(Siragusa et al., 2015)
			Allen Brain Atlas	brain-map.org	(Kuan et al., 2015)
			Edinburgh Mouse Atlas Expression Atlas	emouseatlas.org ebi.ac.uk/gxa	(Richardson et al., 2015; Petryszak et al., 2016)
	Proteomics	Structures Interactions Post-translational modifications	PDB	rcsb.org	(Rose et al., 2015)
			BioGRID	biogrid.org	(Chatr-Aryamontri et al., 2015)
			Pathway Commons	pathwaycommons.org	(Cerami et al., 2011)
			Phosphosite Plus	phosphosite.org	(Hornbeck et al., 2015)
	Transcriptomics, cistromics,		CTDBase	ctd.org	(Davis et al., 2015)
	and epigenomics		DAVID	david.ncifcrf.gov	(Sherman et al., 2007)
			NURSA Transcriptomine	nursa.org/transcriptomine	(Becnel et al., 2015)
			GSEA/mSIGDB	broadinstitute.org/gsea/msigdb	(Liberzon et al., 2015)
			ENCODE	encode.gov	(ENCODE Project Consortium, 2004)
			Ingenuity	ingenuity.com	(www.ingenuity.com)
			NextBio	nextbio.com	(www.nextbio.com)