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Antinociceptive effects of AM4054 and THC. (A) Effects of THC before and after 7-day THC administration (n = 8). (B) Effects of AM4054 before and after 7-day THC administration (n = 8). Ordinates: antinociceptive response, expressed as a percentage of maximum possible effect (%MPE). Abscissae: cumulative drug dose in mg/kg of body weight.
