TABLE 2.
Maximum urine outputs (mean ± S.E.M.) and minimum effective doses (MED)a calculated for ascending and descending limbs of diuresis dose-response curves
| Maximum Output (ml/kg) | MED (mg/kg) | ||
|---|---|---|---|
| Ascending Limb | Descending Limb | ||
| THC control | 30.5 ± 3.6 | 2.2 | NDb |
| 24 h post-THC | 36.3 ± 3.2 | 19.9 | ND |
| 14 days post-THC | 23.8 ± 3.8 | 8.0 | ND |
| AM4054 control | 35.0 ± 5.7 | 0.05 | 0.54 |
| 24 h post-THC | 42.0 ± 2.7 | 0.33 | 2.73 |
| 7 days post-THC | 32.7 ± 2.9 | 0.11 | 1.22 |
| 14 days post-THC | 29.2 ± 3.6 | 0.05 | 0.46 |
| U50,488 control | 37.0 ± 2.3 | 1.6 | ND |
| 24 h post-THC | 26.4 ± 2.0* | 8.4 | ND |
| 7 days post-THC | 25.1 ± 3.0** | 15.3 | ND |
| 14 days post-THC | 30.3 ± 2.9 | 2.7 | ND |
ND, not determined.
a
Minimum effective doses are defined as the lowest dose producing a 0.5-ml/kg increase or decrease outside of the 99% CI of saline and were calculated by interpolation of two points.
b
Descending limb of function was not determined.
*
P < 0.05; **P < 0.01 compared with U50,488 control.