TABLE 3.
Control ED50 values and potency ratiosa at different times after stopping daily THC injections.
| Potency Ratio |
|||||
|---|---|---|---|---|---|
| MED | 24 h | 7 day | 14 day | ||
| THC | Diuresis-ascending | 2.2 mg/kgb | 9.2 | ND | 3.7 |
| Antinociception | 13.2 mg/kg | 7.1 | ND | 4.6 | |
| AM4054 | Diuresis-ascending | 0.05 mg/kgb | 7.0 | 2.3 | 1.0 |
| Diuresis-descending | 0.54 mg/kgb | 5.5 | 2.5 | 1.0 | |
| Antinociception | 0.3 mg/kg | 2.9 | 3.2 | 3.1 | |
ND, not determined.
a
Calculated by dividing the post-THC treatment MED or ED50 values by the baseline MED or ED50 values.
b
Taken from Table 2; included here for clarity.