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. 2016 Aug;358(2):324–333. doi: 10.1124/jpet.116.231928

Fig. 4.

Fig. 4.

The sensitivity of the predicted TCA Ct,Cells to changes in fu,cell,inhibitor as a function of ([I]t,cell/IC50) values for a set of theoretical inhibitors. TCA Ct,Cells in the presence of theoretical inhibitors with different ([I]t,cell/IC50) values were simulated assuming fu,cell,inhibitor = 1 (black bar) and fu,cell,inhibitor = 0.02 (white bar). The fold changes of TCA Ct,Cells compared to baseline (without inhibitors) are plotted on the y-axis.