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Locomotor activity after subcutaneous administration of heroin (A), 6-AM (B), and morphine (C) to mice pretreated with saline or (−)-naloxone (0.01, 0.1, or 1 mg/kg, s.c.). Locomotor activity is given as run distance in centimeters versus time curves at 5-minute intervals (means) (left) and as the maximal distance run (Emax) in centimeters in a 5-minute interval (means + S.E.M.) (right). n = 6–8 in each group. **P < 0.01 (Mann–Whitney U test compared with the saline-pretreated group).
