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Concentration versus time profiles of (−)-naloxone and (+)-naloxone in the blood (A) and brain (B) of mice after a subcutaneous injection of 0.1 mg/kg. Values are given as means ± S.E.M. n = 4–6 at each sample point. *P < 0.05; **P < 0.01 (Mann–Whitney U test between treatment groups).
