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Effect of PF-06655075 (PF1) on fear-induced freezing. Peripheral administration of PF1 inhibits freezing to a similar degree as propranolol in response to both context (a) and context + cue (b). However, multidose administration of OT does not significantly inhibit freezing in either context (b) or context + cue (c). Central administration of PF1, PF2, and OT inhibits the expression of freezing to both context (e) and context + cue (f). *P < 0.05; **P < 0.01; ***P < 0.001.
