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| Compound Name and Description | Oxytocin (OT) | PF-06655075 (PF1) | PF-06478939 (PF2) |
|---|---|---|---|
| nM | |||
| OTR agonist EC50 | 0.039 (n = 70) | 0.025 (n = 5) | 0.01 (n = 6) |
| OTR % agonist | 100 (n = 70) | 93 (n = 5) | 92 (n = 6) |
| OTR binding Ki | 0.48 (n = 7) | 0.037 (n = 1) | 0.076 (n = 2) |
| V1a agonist EC50 | 7.66 (n = 70) | >10,000 (n = 5) | 0.078 (n = 3) |
| V1a % agonist | 94 (n = 70) | N/A | 97 (n = 3) |
| V1a Ki (nM) | 16.1 (n = 8) | 4.37 (n = 7) | 0.327 (n = 2) |
OTR, oxytocin receptor.
