TABLE 4.
Percent basal surface levels and 95% confidence intervals of CB2 receptors
The results represent data obtained after treatment with select ligands (at their EC90 concentrations for inhibition of adenylyl cyclase or stimulation of arrestin recruitment).
| Treatment |
Basal Level (Mean ± S.E.M.) |
95% CI |
|---|---|---|
| % | ||
| Control | 99 ± 1.2 | 97–101 |
| CP55940 | 78 ± 2.3 | 74– 80 |
| 2AG | 99 ± 1.1 | 96–103 |
| THC | 100 ± 2.4 | 92–105 |
| HU308 | 95 ± 3.3 | 90–103 |
| GW833972A | 69 ± 3.0 | 66–72 |
| STS135 | 85 ± 3.3 | 76–89 |
| UR144 | 76 ± 2.1 | 73–80 |
CI, confidence interval; GW833972A, 2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide hydrochloride; HU308, 4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol; THC, tetrahydrocannabinol.