Fig. 1.

Overview of the cholesterol biosynthetic pathway. Cholesterol synthesis inhibitors and their enzymatic targets are indicated. CYP51, lanosterol 14α-demethylase; FPPS, farnesyl pyrophosphate synthase; GGPP, geranylgeranyl pyrophosphate; GGPPS, geranylgeranyl pyrophosphate synthase; HMGCS1, 3-hydroxy-3-methylglutaryl coenzyme A (CoA) synthase 1; IDI1/2, isopentenyl-diphosphate delta isomerase 1 and 2; LSS, lanosterol synthase; MVD, mevalonate diphosphate decarboxylase; MVK, mevalonate kinase; PMVK, phosphomevalonate kinase; SQS, squalene synthase; SQE, squalene epoxidase.