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. 2016 Aug;358(2):199–208. doi: 10.1124/jpet.115.229344

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Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 4. — Effects of ME-344 on bioenergetics and redox stress in IHLEF and lung cancer cells. HPLC analyses of (A) ATP and (B) GSSG in intact (DMSO, black bars) and ME-344 treated (11.48 µM, white bars) sensitive (SENS) or resistant (RES) cell lysates. Data were averaged for sensitive (H460, SHP-77) or resistant (H596, SW900) cells and presented as mean ± S.D. for three independent experiments. HPLC analyses of ME-344 dose effects on ATP/ADP ratios (black bars) and GSSG (normalized for its value before treatment, gray bars) in (C) IHLEF (MRC-5) or (D) sensitive cells (H460) are presented as mean ± S.E. for three independent experiments. ATP/ADP changes in sensitive (H460) cells were statistically different (P ≤ 0.05).