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. 2016 Aug;358(2):199–208. doi: 10.1124/jpet.115.229344

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Fig. 5. — Me-344 effects on caspase-3 activation and cell viability. (A) The kinetics of ME-344 (11.4 μM) inhibition of caspase-3 activity (normalized for DMSO) in H596 and SW-900 (resistant: □ and ○), H460 and SHP-77 (sensitive: ▪ and ●) and MRC-5 (IHLEF, ★). (B) Temporal viability of sensitive (▪ and ●) and resistant (□ and ○) cells and of IHLEF (MRC-5, ★) after ME-344 (11.48 μM). (C) Dose effects of ME-344 on caspase-3 activity in all cell types. (D) Viabilities of sensitive (H460) and resistant (H596) cells and IHLEF (MRC-5) after 24 hours’ incubation with ME-344 (5.74 and 11.48 µM). Data are mean ± S.D. for three independent experiments.