Fig. 6.

ME-344 treatments linked with hydrogen peroxide and *OH generation. (A, C) ME-344 (11.4 μM) effects on intracellular H₂O₂ (*OH) generation in H460 sensitive (black traces) and H596 resistant (gray traces) cells in real-time kinetics. The traces are representative of three independent experiments and similar for SHP-77 (sensitive) and SW900 (resistant) cells. (B, D) Averaged dose effects of ME-344 on intracellular generation of averaged H₂O₂ (*OH) in sensitive (H460 and SHP-77, ●) and resistant (H596 and SW900, ○) cells and IHLEF (MRC-5, ★) as mean ± S.D. for three independent experiments, where the effects are statistically different (P ≤ 0.001). The lines represent sigmoid fit (three parameters) using Sigma Plot software. The arrows indicate points where effector was added.