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. 2016 Aug;358(2):199–208. doi: 10.1124/jpet.115.229344

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Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 8. — ME-344 effects on dynamics of intra- and extracellular thiol redox status in lung cancer and IHLEF cells. Averaged reduced thiol (sulfhydryls) dynamics in lysates of (A) sensitive (H460 and SHP-77), and (B) IHLEF (MRC-5) before (DMSO control [CTR], ● and ★) and after incubation with ME-344 (22.8 μM, ○ and ☆), analyzed with sulfhydryl-specific fluorescent dye TG-1. Emissions were normalized for protein concentrations and presented as mean ± S.E. for three independent experiments. (C) Sensitive (H460 and SHP-77 cells) and (D) IHLEF (MRC-5) were treated with ME-344 (22.8 μM) for the indicated times, and cell surface thiol (sulfhydryls) were detected with TG-1. Emissions were normalized for cell numbers, and are averaged and presented as mean ± S.E. for three independent experiments.