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. 2016 Aug;358(2):306–314. doi: 10.1124/jpet.115.229492

Fig. 1.

Fig. 1.

Effects of CP55,940, AEA, and SA-57 on the percentage of responses in training drug-paired apertures and response rates in C57BL/6J mice trained to discriminate CP55,940 (0.1 mg/kg; (A, B) or FAAH (−/−) mice trained to discriminate AEA (6 mg/kg; C, D). (A) Dose-dependent generalization of CP55,940 and dose-dependent substitution of SA-57 for the CP55,940-discriminative stimulus. The respective ED50 (95% confidence interval [CI]) values for CP55,940 generalization and SA-57 substitution in C57BL/6J mice were 0.04 (0.03–0.05) mg/kg and 2.4 (1.6–3.6) mg/kg. (B) CP55,940 (0.2 mg/kg), but not SA-57, significantly decreased rates of responding compared with vehicle. (C) Dose-dependent generalization of AEA and dose-dependent substitution of SA-57. The respective ED50 (95% CI) values for AEA and SA-57 in FAAH (−/−) mice were 2.7 (2.3-3.1) mg/kg and 3.1 (2.8–3.4) mg/kg. (D) SA-57 (17 mg/kg) and AEA (30 mg/kg) decreased rates of responding. Values represent mean ± S.E.M. Filled symbols indicate significant difference (P < 0.001) versus vehicle; n = 7-10 mice/group.