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Substitution experiments of noncannabinoid psychoactive drugs nicotine (1.5 mg/kg) and diazepam (10 mg/kg) for the SA-57 training dose. (A) Nicotine did not substitute, whereas diazepam partially substituted for the SA-57 training dose. (B) Nicotine (1.5 mg/kg) and diazepam (10 mg/kg) significantly reduced the rates of responding. Values represent mean ± S.E.M. Asterisks indicate significant difference (P < 0.05) versus vehicle; n = 7 to 8 mice/group.
