TABLE 1.

Cannaboid 1 receptor (CB₁) receptors mediate the discriminative stimulus effects of the SA-57 (10 mg/kg) training dose

The CB₁ receptor antagonist rimonabant (3 mg/kg) significantly blocked the discriminative stimulus effects of SA-57 (10 mg/kg) as well as substitution of CP55,940 (0.1 mg/kg). The CB₂ receptor antagonist SR144528 (3 mg/kg), the TRPV1 receptor antagonist capsazepine (5 mg/kg), and the PPARα receptor antagonist GW6471 (2 mg/kg) did not block the SA-57 (10 mg/kg) discriminative stimulus. The vehicle-vehicle and rimonabant-vehicle conditions are the same as those used in Fig. 9. Values represent mean ± S.E.M. n = 6–8 mice/group.

Drug	Antagonist	% SA-57 Substitution ± S.E.M.	Nose Pokes/min ± S.E.M.
Vehicle	Vehicle	12.8 ± 9.4	38.9 ± 3
	Rimonabant	4.0 ± 1.2	24.9 ± 3
	SR144528	0.7 ± 0.3	36.6 ± 3.8
	Capsazepine	1.3 ± 0.4	20.1 ± 2.6
	GW6471	0.3 ± 2.6	24.6 ± 3.1
SA-57	Vehicle	95.7 ± 1.7	27.3 ± 1.9
	Rimonabant	3.4 ± 1.2	20.1 ± 2.5
	SR144528	98 ± 1.5	30.5 ± 5.4
	Capsazepine	86 ± 12.2	15.7 ± 2.9
	GW6471	96.5 ± 1.3	19.0 ± 2
CP55,940	Vehicle	82.5 ± 11	33.1 ± 3.3
	Rimonabant	10.4 ± 5.7	20.7 ± 4.9