TABLE 2.
Fatty acid amide hydrolase (FAAH) inhibitors (PF-3845 and URB597), ABHD6 inhibitors (KT182 and KT195), and the cyclooxygenase-2 (COX2) selective inhibitor valdecoxib do not substitute for the discriminative stimulus effects of SA-57 (10 mg/kg) in C57BL/6J mice and do not affect response ratesa
| Enzyme | Drug (mg/kg) | % SA-57 Substitution | Nose Pokes/Min |
|---|---|---|---|
| mg/kg | ±S.E.M. | ±S.E.M. | |
| FAAH | Vehicle | 0.6 ± 0.5 | 47.5 ± 4.9 |
| PF-3845 (10) | 1.5 ± 0.5 | 34.4 ± 3.8 | |
| PF-3845 (30) | 0.7 ± 0.2 | 38.9 ± 3.5 | |
| URB597 (10) | 2.1 ± 1.0 | 36.9 ± 5.6 | |
| ABHD6 | Vehicle | 1.1 ± 0.6 | 46.5 ± 2.6 |
| KT182 (1) | 1.4 ± 0.7 | 41.1 ± 3.5 | |
| KT182 (2) | 1.4 ± 0.8 | 43.5 ± 2.4 | |
| KT195 (40) | 0.8 ± 0.3 | 38.1 ± 3.1 | |
| COX2 | Vehicle | 1.1 ± 0.6 | 46.5 ± 2.6 |
| Valdecoxib (10) | 1.1 ± 0.7 | 31.9 ± 3.9 |
a
Values represent mean ± S.E.M.; n = 7 or 8 mice/group.