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Effects of Mrp2 knockout or NASH on systemic exposure to pemetrexed. Plasma concentration of pemetrexed over 120 minutes after intravenous administration of 10 mg/kg pemetrexed to wild-type (closed circles) and Mrp2−/− (open squares) rats (A) or control (closed circles) and MCD (open squares) rats (B). Corresponding plasma AUC graphs represent means ± S.D. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 (Student’s t test). Wild-type and Mrp2−/−, n = 3; control, n = 4, and MCD, n = 5.
