Fig. 1.

2010 American Association of Clinical Endocrinologists (AACE) Clinical Practice Guideline (CPG) methodology. Current AACE CPGs have a problem-oriented focus that results in a shortened production time line, middle-range literature searching, emphasis on patient-oriented evidence that matters, greater transparency of intuitive evidence rating and qualifications, incorporation of subjective factors into evidence-recommendation mapping, cascades of alternative approaches, and an expedited multilevel review mechanism.