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Treatment sequences for HER2-positive metastatic breast cancer.
| Sequences | First line | Second line | Third line |
|---|---|---|---|
| 1 | Pertuzumab + trastuzumab + docetaxel | T-DM1 | Capecitabine + lapatinib |
| 2 | Pertuzumab + trastuzumab + docetaxel | Trastuzumab + lapatinib | Trastuzumab + capecitabine |
| 3 | Trastuzumab + docetaxel | T-DM1 | Trastuzumab + lapatinib |
| 4 | Trastuzumab + docetaxel | Trastuzumab + lapatinib | Trastuzumab + capecitabine |
T-DM1: trastuzumab emtansine.
