Table 2.

Significant KEGG pathways for G2.

Pathway	Overlapping genes	p-value	q-value
Cholinergic synapse	CREB3L2; GNG4; CACNA1C; ADCY9; CHRNA7	0.002	0.015
Hypertrophic cardiomyopathy (HCM)	CACNA1C; ITGB6; ACE; CACNB4	0.004	0.015
GABAergic synapse	GABRB1; GNG4; CACNA1C; ADCY9	0.005	0.015
Insulin secretion	CREB3L2; CACNA1C; ADCY9; ADCYAP1	0.005	0.015
Dilated cardiomyopathy	CACNA1C; ITGB6; ADCY9; CACNB4	0.006	0.015
Circadian entrainment	GRIN2B; GNG4; CACNA1C; ADCY9	0.007	0.015
Rap1 signaling pathway	TEK; PDGFD; ADCY9; DOCK4; GRIN2B; SIPA1L1	0.007	0.015
Adrenergic signaling in cardiomyocytes	CREB3L2; ADRB2; CACNA1C; ADCY9; CACNB4	0.008	0.015
Retrograde endocannabinoid signaling	GABRB1; GNG4; CACNA1C; ADCY9	0.008	0.015
Endocytosis	VPS37C; NTRK1; AGAP1; ADRB2; TFRC; HSPA1L	0.008	0.015
Glutamatergic synapse	GRIN2B; GNG4; CACNA1C; ADCY9	0.011	0.020
Neuroactive ligand–receptor interaction	NTSR2; GRIN2B; ADRB2; CHRNA7; GABRB1; HCRTR2	0.014	0.023
Dopaminergic synapse	CREB3L2; GRIN2B; GNG4; CACNA1C	0.019	0.027
cAMP signaling pathway	CREB3L2; GRIN2B; ADRB2; CACNA1C; ADCY9	0.020	0.027
Ras signaling pathway	GRIN2B; GNG4; TEK; PDGFD; RASGRF2	0.034	0.043

KEGG, Kyoto Encyclopedia of Genes and Genomes; GABA, gamma-aminobutyric acid; Rap1, Ras-related protein 1; cAMP, Cyclic adenosine monophosphate.