Table 1.
Characteristics of the cohort according to the TNFA rs1800629 genotypes
| Variable | GG (n = 182) | GA (n = 66) | AA (n = 14) | p |
|---|---|---|---|---|
| Age, years | 65±16 | 66±15 | 70±12 | 0.485 |
| Men | 92 (50.6) | 38 (57.6) | 8 (57.1) | 0.583 |
| White ethnicity | 161 (88.5) | 62 (93.9) | 14 (100) | 0.198 |
| BMI, kg/m2 | 30±9 | 30±7 | 33±7 | 0.432 |
| Coexisting conditions | ||||
| Diabetes mellitus | 79 (43.4) | 30 (45.5) | 7 (50.0) | 0.870 |
| Heart failure | 30 (16.5) | 9 (13.6) | 3 (21.4) | 0.736 |
| Sepsis | 76 (41.8) | 30 (45.5) | 6 (42.9) | 0.874 |
| Baseline eGFR <60 ml/min/1.73 m2 | 118 (65.9) | 44 (69.8) | 12 (85.7) | 0.291 |
| AKI stage | ||||
| Stage 1 | 85 (46.7) | 23 (35.4) | 4 (28.6) | 0.268 |
| Stage 2 | 6 (3.3) | 5 (7.7) | 1 (7.1) | |
| Stage 3 | 91 (50.0) | 37 (56.9) | 9 (64.3) | |
| Cause of AKI | ||||
| Ischemic | 64 (35.4) | 23 (34.9) | 7 (50.0) | 0.794 |
| Nephrotoxic | 30 (16.6) | 11 (16.7) | 0 (0.0) | |
| Sepsis | 19 (10.5) | 4 (6.1) | 1 (7.1) | |
| Atheroembolic | 9 (5.0) | 4 (6.1) | 1 (7.1) | |
| Other/unknown/multifactorial | 59 (32.6) | 24 (36.4) | 5 (35.7) | |
| ICU admission | 133 (73.1) | 48 (72.7) | 11 (78.6) | 0.898 |
| Assisted mechanical ventilation | 46 (25.3) | 13 (19.7) | 3 (21.4) | 0.646 |
| APACHE II score | 20±7 | 19±5 | 21±8 | 0.428 |
| Enrollment serum cystatin C, mg/l | 3.0±1.2 | 3.1±1.1 | 4.0±1.7 | 0.039 |
| Serum creatinine, mg/dl | ||||
| Enrollment | 3.4±1.6 | 3.9±2.0 | 4.0±1.6 | 0.084 |
| Peak | 4.0±1.9 | 5.2±3.9 | 4.8±1.9 | 0.004 |
| Discharge | 2.3±1.4 | 3.1±2.3 | 2.0±0.9 | 0.004 |
| Urinary tubular injury marker | ||||
| KIM-1, ng/mg | 2.9 (1.2, 7.4) | 4.9 (2.4, 9.3) | 6.7 (3.3, 9.3) | 0.034 |
| NAG, mU/mg | 39.9 (17.0, 87.6) | 29.6 (12.1, 76.3) | 32.7 (15.7, 114.9) | 0.333 |
| α-GST, ng/mg | 15.6 (6.0, 35.7) | 10.7 (3.7, 29.8) | 19.3 (7.9, 50.1) | 0.458 |
| π-GST, ng/mg | 274.0 (97.0, 826.9) | 274.5 (61.8, 1,062.5) | 1,397.3 (1,164.7, 2,440.9) | 0.031 |
| Oliguria, % | 33 (18.4) | 14 (21.9) | 4 (28.6) | 0.589 |
| Dialysis requirement | 68 (37.4) | 27 (40.9) | 8 (57.1) | 0.329 |
| In-hospital death | 39 (21.4) | 13 (19.7) | 5 (35.7) | 0.411 |
Continuous variables are presented as means (SD) or medians (25th and 75th percentile), and categorical variables as n (%).