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. Author manuscript; available in PMC: 2017 Mar 7.
Published in final edited form as: Curr Biol. 2016 Feb 18;26(5):616–626. doi: 10.1016/j.cub.2015.12.069

Figure 2. Simulation of Architecture-Dependent Contractility of Actin Rings.

Figure 2

(A) Simulated contractility of actin rings with different architectures. The essential features of the three types of actin rings were constructed within the cytosim platform (green, disordered network; red, ordered bundles; blue, disordered bundles) and simulated (see text). The diameter of the rings is 9 µm.

(B) Measured ring perimeter, for each type of ring, as a function of time. The simulated dynamics of ring contraction in the presence of motors were generated from ten simulations in each case.

(C) Effect of polymer rigidity on ring deformation. Simulations were identical as in (A) but with an infinite polymer rigidity. Dark curves correspond to Lp = 15 µm. Light curves were obtained with straight filaments, corresponding to infinite Lp.

(D) Estimation of actin filaments buckling during ring deformation. The curvature (inverse of the radius of curvature) was determined as the average filament curvatures for the entire ring (see Experimental Procedures).

See also Figures S2 and S3 and Movie S4.