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. 2016 Jul 8;7:2041731416656148. doi: 10.1177/2041731416656148

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — In vivo assessment of bone repair at 14 days. Representative photomicrographs of granulation tissue and new bone formation (arrows) in 14-day fractures treated with (a) scaffold only, (b) MAPC + DBM scaffold, or (c) MSC + DBM scaffold. In fractures treated with (a) scaffold only, a fibroblastic response is present around the cellular scaffold fragments (*). In fractures treated with (b) MAPC or (c) MSC in addition to the scaffold, mesenchymal cells produce osteoid (arrows) or chondroid extracellular matrix with partial incorporation of acellular scaffold fragments. Hematoxylin and eosin stain, 40× magnification. Results indicated that MAPC + DBM scaffold groups had significantly more (d) woven and (e) lamellar bone when compared to the scaffold-only group. (f) MAPC + DBM scaffold groups had significantly more total bone when compared to scaffold-only and MSC + DBM scaffold groups (n = 20 each, *p < 0.001).