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Structural model of the Myo1c/Neph1-CD complex. (A) Myo1c and Neph1-CD proteins are depicted in red and magenta surface representation. The three calmodulins bound to the IQ domain of Myo1c are shown in green, blue, and cyan surface representation mode. The residues K761 and THV (PDZ-binding residues) in Neph1-CD are present in interaction interface. (B) The binding site for ZO1-PDZ1 (yellow) in Neph1-CD (magenta ribbon) is occluded when Neph1-CD interacts with Myo1c.
