FIG 4.
Deficiency in JAK1 inhibits the expression of downstream transcriptional target genes that are normally upregulated during mammary gland involution. (A) Gene set enrichment plots with heat maps of genes that are selectively upregulated during the second day of involution compared to their regulation during lactation. TGF-β, transforming growth factor β. (B) Heat maps of selected genes that are normally upregulated during involution but that exhibit a 2-fold or more downregulation in females with mammary gland-specific JAK1 knockout (MMTV-Cre Jak1fl/fl) compared to their regulation in the wild-type controls (Jak1fl/fl) on the second day of involution.