Table 1.

Mapping of communication blocks between wild-type KIT and the D816V mutant

Wild type
Name	A	B	C	D	E	F	G	H	I	J	K	-	-
Size (res.)	22	11	32	16	14	13	11	127	160	9	4	-	-
Mutant
Name	-	B’	C’	D’	-	-	G’	H’	I’	J’	-	L’	M’
Size (res.)	-	12	20	18	-	-	10	86	186	8	-	35	66
Overlap (%)	-	96	65	76	-	-	95	80	87	71	-	-	-

The overlap o _ij between two blocks B _i and B _j, identified in the wild type and in the mutant, is evaluated as: o _ij=2∗#(B _i∩B _j)/(#(B _i)+#(B _j)). Two blocks are defined as counterparts, namely X and X’ if: (i) X’ (resp. X) yields the maximum overlap with X (rest. X’) over all blocks in the mutant (resp. wild-type) protein; (ii) the overlap is greater than 60%