Table 2.

Top tier ranked up to 10th associated diseases

Target Disease	Associated via Reference Network		Associated via Complemented Network
Celiac Disease	Diabetes Mellitus Metabolic Syndrome X Glucose Intolerance Hyperinsulinism Hyperlipidemias	Calcinosis Dyslipidemias Hyperhomocysteinemia Anemia, Iron-Deficiency Homochromatosis	Diabetes Mellitus† Metabolic Syndrome X† Glucose Intolerance† Hyperinsulinism† Congentital Hyperinsulinism**	Malabsorption Syndromes* Hypoglycemia** Dyslipidemais† Hyperglycemia** Hyperhomocysteinemia†
Lactose Intolerance	Diabetes Mellitus Metabolic Syndrome X Glucose Intolerance Celiac Disease Dyslipidemias	Hyperinsulinism Amyotrophic Lateral Sclerosis Insulin Resistance Hyperlipidemias Glucose Metabolism Disorders	Mucolipidoses* Celiac Disease* Glycogen Storage Disease* Metabolism, Inborn Errors* Malabsorption Syndromes*	Diabetes Mellitus† Hypoglycemia** Hyperinsulinism** Glucose Intolerance** Hypokalemia*
Hypophosphatasia	Metabolic Syndrome X Diabetes Mellitus Glucose Intolerance Metabolic Diseases Dyslipidemias	Amyotrophic Lateral Sclerosis Diabetes, Gestational Hyperlipidemias Hyperinsulinism Calcinosis	Acidosis, Renal Tubular* Zellweger Syndrome* Celiac Disease* Peroxisomal Disorders** Refsum Disease*	Metabolism, Inborn Errors* Adrenoleukodystrophy* Homocystinuria** Diabetes Mellitus† Phenylketonurias*
Refsum Disease	Zellweger Syndrome Peroxisomal Disorders Chondrodysplasia Punctata, Rhizomelic Adrenoleukodystrophy Homocystinuria	Porphyrias Protoporphyria, Erythropoietic Hyperhomocysteinemia Diabetic Ketoacidosis Lipid Metabolism, Inborn Errors	Neuronal Ceroid-Lipofuscinoses* Lipidoses* Peroxisomal Disorders† Zellweger Syndrome† Diabetes Mellitus*	Leigh Disease* Glycogen Storage Disease* Adrenoleukodystrophy† Malabsorption Syndromes* Glucose Intolerance**
Fanconi Syndrome	Hypophosphatemia Glycogen Storage Disease Hypercalcemia Glucose Intolerance Metal Metabolism, Inborn Errors	Osteomalacia Xanthomatosis, Cerebrotendinous Diabetes Mellitus Calcinosis Metabolic Syndrome X	Celiac Disease* Glycogen Storage Disease† Diabetes Mellitus† Carbohydrate Metabolism, Inborn Errors* Leigh Disease*	Diabetes, Gestational* Glucose Intolerance† Hyperinsulinism* Hypoglycemia* Congenital Hyperinsulinism**
Menkes Kinky Hair Syndrome	N/A		Congenital Disorders of Glycosylation* Hyperglycinemia, Nonketotic* Zellweger Syndrome* Peroxisomal Disorders** Hepatolenticular Degeneration*	Refsum Disease** Acidosis, Lactic* Albinism* Mitochondrial Myopathies* Adrenoleukodystrophy**
Pyruvate Carboxylase Deficiency Disease	N/A		Acidosis, Renal Tubular* Carbohydrate Metabolism, Inborn Errors* Hyperglycinemia, Nonketotic* Maple Syrup Urine Disease* Glycogen Storage Disease*	Amino Acid Metabolism, Inborn Errors* Renal Aminoacidurias** Metabolism, Inborn Errors* Acidosis, Lactic* Pyruvate Metabolism, Inborn Errors*
Rothmund-Thomson Syndrome	N/A		DNA Repair-Deficiency Disorders* Celiac Disease* Metal Metabolism, Inborn Errors** Acidosis* Xanthomatosis, Cerebrotendinous**	Hypercalcemia* Skin Diseases, Metabolic* Amyloidosis, Familial* Achlorhydria** Osteomalacia**
Sphingolipidoses	N/A		Neuronal Ceroid-Lipofuscinoses* Lipidoses* Carbohydrate Metabolism, Inborn Errors* Diabetes Mellitus* Peroxisomal Disorders*	Zellweger Syndrome** Glycogen Storage Disease* Adrenoleukodystrophy* Refsum Disease* Glucose Intolerance**
Alkaptonuria	N/A		Carbohydrate Metabolism, Inborn Errors* Glycogen Storage Disease* Zellweger Syndrome* Metabolism, Inborn Errors* Peroxisomal Disorders**	Amino Acid Metabolism, Inborn Errors* Refsum Disease* Adrenoleukodystrophy** Diabetes Mellitus* Lipid Metabolism, Inborn Errors*

Notations ‘^†’, ‘*’ and ‘**’ are identical to those in Fig. 5