Table 1.
Physiological Parameters
| Parameter | Surgery groups | 15 min prior | 15 min post | 1 hr post | 2 hr post | 3 hr post | 4 hr post |
|---|---|---|---|---|---|---|---|
| Weight | Sham | 372.2±15.1 | |||||
| (g) | Normothermic mTBI | 348.7±9.9 | |||||
| Hyperthermic mTBI | 346.0±11.2 | ||||||
| Hyperthermic/normothermic mTBI | 347.9±9.2 | ||||||
| ATM | Normothermic mTBI | 1.47±0.01 | |||||
| Hyperthermic mTBI | 1.51±0.02 | ||||||
| Hyperthermic/normothermic mTBI | 1.51±0.01 | ||||||
| MABP | Sham | 124.3±3.7 | 120.1±3.9 | 115.5±3.4 | 113.1±3.6 | 108.6±2.6 | 110.7±3.7 |
| (mmHg) | Normothermic mTBI | 117.8±4.4 | 117.2±3.4 | 111.0±2.4 | 108.3±3.6 | 106.5±1.9 | 108.6±1.9 |
| Hyperthermic mTBI | 118.6±3.3 | 111.4±2.8 | 103.7±1.4 | 101.0±1.8 | 101.6±0.3 | 105.6±3.9 | |
| Hyperthermic/normothermic mTBI | 121.1±3.4 | 115.1±2.5 | 108.5±1.8 | 105.8±1.5 | 109.5±2.2 | 112.6±3.3 | |
| BloodpO2 | Sham | 146.0±7.0 | 140.9±5.8 | 139.4±7.6 | 131.8±8.7 | 131.5±10.9 | 137.4±12.1 |
| (mmHg) | Normothermic mTBI | 165.6±7.4 | 148.8±7.8 | 145.0±6.6 | 145.6±7.9 | 149.0±5.0 | 135.8±5.6 |
| Hyperthermic mTBI | 137.1±6.1 | 137.1±9.0 | 140.4±8.3 | 137.6±11.5 | 126.8±4.5 | 124.6±5.1 | |
| Hyperthermic/normothermic mTBI | 138.1±4.2 | 119.9±3.8 | 136.5±6.0 | 138.3±9.5 | 137.5±4.4 | 135.9±8.6 | |
| BloodpCO2 | Sham | 38.4±0.9 | 38.6±0.7 | 37.4±0.7 | 38.5±0.9 | 38.1±1.1 | 37.7±0.7 |
| (mmHg) | Normothermic mTBI | 39.2±0.6 | 37.4±0.4 | 37.5±0.4 | 38.5±0.5 | 37.7±0.5 | 38.5±0.7 |
| Hyperthermic mTBI | 39.1±0.8 | 37.6±0.4 | 37.3±0.6 | 37.7±0.4 | 37.2±0.4 | 37.3±0.5 | |
| Hyperthermic/normothermic mTBI | 38.1±0.7 | 38.0±0.6 | 37.3±0.5 | 38.4±0.6 | 37.1±0.5 | 37.1±0.4 | |
| Blood pH | Sham | 7.47±0.01 | 7.47±0.01 | 7.45±0.02 | 7.45±0.01 | 7.45±0.01 | 7.45±0.01 |
| Normothermic mTBI | 7.44±0.01 | 7.46±0.01 | 7.46±0.01 | 7.45±0.01 | 7.45±0.01 | 7.44±0.01 | |
| Hyperthermic mTBI | 7.44±0.01 | 7.44±0.01 | 7.44±0.01 | 7.44±0.01 | 7.45±0.01 | 7.45±0.01 | |
| Hyperthermic/normothermic mTBI | 7.45±0.01 | 7.45±0.01 | 7.45±0.01 | 7.45±0.01 | 7.45±0.00 | 7.45±0.01 | |
| Head | Normothermic Sham | 36.7±0.1 | 36.7±0.1 | 36.9±0.1 | 36.9±0.1 | 36.9±0.0 | 36.7±0.1 |
| Temperature | Hyperthermic Sham | 38.6±0.1 | 38.6±0.0 | 38.6±0.0 | 38.7±0.1 | 38.8±0.0 | 38.7±0.0 |
| (°C) | Normothermic mTBI | 36.8±0.0 | 36.7±0.1 | 36.8±0.1 | 36.9±0.1 | 37.0±0.1 | 36.9±0.1 |
| Hyperthermic mTBI | 38.7±0.0 | 38.7±0.0 | 38.7±0.0 | 38.7±0.0 | 38.8±0.1 | 38.9±0.0 | |
| Hyperthermic/normothermic mTBI | 38.7±0.0 | 38.6±0.0 | 37.0±0.1c | 37.0±0.1c | 37.0±0.1c | 36.9±0.0c | |
| Body | Normothermic Sham | 36.9±0.0 | 36.9±0.1 | 36.7±0.0 | 36.8±0.1 | 36.7±0.1 | 36.8±0.1 |
| Temperature | Hyperthermic Sham | 38.9±0.1 | 39.0±0.1 | 38.7±0.1 | 38.6±0.0 | 38.7±0.1 | 38.8±0.0 |
| (°C) | Normothermic mTBI | 36.9±0.0 | 36.9±0.1 | 36.8±0.0 | 36.9±0.1 | 36.9±0.0 | 36.9±0.0 |
| Hyperthermic mTBI | 38.9±0.0 | 38.8±0.1 | 38.9±0.1 | 38.8±0.1 | 38.8±0.0 | 39.0±0.1 | |
| Hyperthermic/normothermic mTBI | 38.9±0.0 | 38.8±0.0 | 37.0±0.0c | 36.8±0.0c | 36.7±0.0c | 36.9±0.1c | |
ATM, atmospheric pressure; MABP, mean arterial blood pressure
c
p<0.001 vs 15 min prior or 15 min post, repeated measures two-way ANOVA and Tukey post-hoc analysis