Skip to main content
. Author manuscript; available in PMC: 2016 Jul 25.
Published in final edited form as: J Nucl Med. 2016 Feb 2;57(5):771–776. doi: 10.2967/jnumed.115.167072

FIGURE 6.

FIGURE 6

Ex vivo analysis of OVCAR3 tumors after PET imaging. (A) Hematoxylin and eosin–stained OVCAR3 tumor section outlining the architecture of the tumor. (B) Digital autoradiograph demonstrating the distribution of 89Zr-DFO-mAb-B43.13 within the tumor. (C) Hoechst 33342 dye (blue) fluorescence map of the tumor vasculature. (D) Overlay of the digital autoradiograph with the Hoechst dye fluorescence map illustrating the role of vasculature in the heterogeneous and limited distribution of 89Zr-DFO-mAb-B43.13 in the tumor. Bottom row contains higher-magnification images of the corresponding sections A–D from the boxed area shown in 6B.