Table 3.

EC₅₀ (μM) values^a for PTL (1), and MMB derivatives 7a-7j and 8 against M9-ENL1 cells and primary AML cell specimens

Comp	M9-ENL1	AML01	AML02	AML03	AML04	AML01
1	6	16	2.5	5	8	7
7a	1.0	2.6	2.3	ND	ND	3.7
7b	1.5	2.2	2.0	7.3	4.2	2.0
7c	0.6	1.6	0.9	ND	3.5	1.6
7d	1.5	1.6	1.2	3.5	3.7	1.7
7e	1.1	1.7	1.3	5.7	3.6	2.4
7f	2.0	2.6	1.2	2.9	3.7	2.3
7g	2.0	1.9	1.5	2.4	3.7	3.2
7h	2.9	2.3	2.0	2.9	4.2	3.3
7i	1.2	0.9	ND	ND	2.7	2.7
7j	2.4	ND	ND	1.2	ND	ND
8	0.5	1.6	0.8	ND	ND	ND

^aEC₅₀ values <1 μM are bolded, ND = not determined