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. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: ACS Appl Mater Interfaces. 2016 Jul 7;8(28):17955–17963. doi: 10.1021/acsami.6b05840

Figure 4.

Figure 4

Comparison of nanoparticle pharmacokinetics in the blood pool, liver, and ischemic hindlimb between naïve and re-injected mice. (a) Blood pool activity in the naïve group was consistently higher than that of the re-injected group. (b) Liver uptake of nanoparticle at 72 h after injection was compared between the naïve and re-injected group. Liver uptake was higher in the re-injected group than the naïve group at Day 10 and 17 post-surgery. (c) Nanoparticle uptake in the ischemic hindlimb at 72 h post-injection was higher in the naïve group than the re-injected group at Day 10 and 17. Each value represents the mean ± SD (n=4). Naïve vs. Re-injected, * : p < 0.05, ** : p < 0.01, *** : p < 0.001.