Figure 6. Na-Fluo or Fl-MTX uptake at acidic pH in Sf9 cells overexpressing the entire human OATP panel.
Sf9 cells overexpressing OATPs (see axis x) were incubated with 1 μM Na-Fluo (A) or 1 μM Fl-MTX (B) for 10 minutes at 37°C in buffer pH 5.5 (panel A) or pH 6.5 (panel B). Columns show geomean fluorescence. Bars represent an average of three independent experiments +/− SD values. Significantly different from the control: * p< 0.05, ** p<0.01, *** p<0.001.