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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Biochem Pharmacol. 2015 Sep 28;98(4):649–658. doi: 10.1016/j.bcp.2015.09.015

Figure 7. Effect of various compounds on the accumulation of Fl-MTX in insect cells overexpressing OATP1B1, 1A2 or 2B1.

Figure 7

Cells were incubated with 1 μM Fl-MTX at pH 6.5 for 10 minutes in the presence or absence of various compounds. Columns represent activity as a percentage of non-treated (control) fluorescence measured without the added inhibitors/substrates. Measurements were repeated at least four times, columns show average +/− SD values. Striped bars indicate newly identified interactions. * p< 0.05, ** p<0.01 and *** p<0.001 indicate significant difference from the non-treated control.

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