Table 1.
Baseline demographics and disease characteristics
| Demographics and characteristics | Overall population (N=3,974) | Excluded from per-protocol population (N=1,954) |
|---|---|---|
| Sex, n (%) | ||
| Male | 2,362 (59.4) | 1,176 (60.2) |
| Female | 1,612 (40.6) | 774 (39.8) |
| Age (years), mean (SD) | 65.7 (10.1) | 65.7 (10.6) |
| Age groups, n (%) | ||
| <65 years | 1,809 (45.5) | 903 (46.2) |
| 65–75 years | 1,492 (37.5) | 670 (34.3) |
| >75 years | 673 (16.9) | 381 (19.5) |
| BMI (kg/m2), mean (SD) | 27.3 (5.6) | 27.2 (5.6) |
| Duration since primary diagnosis, n (%) | ||
| ≤1 year | 963 (24.2) | 619 (31.7) |
| >1 year | 3,011 (75.8) | 1,335 (68.3) |
| FEV1 (percent predicted),a n (%) | ||
| ≥80 | 733 (18.4) | 355 (18.2) |
| 50 to <80 | 1,948 (49.0) | 947 (48.5) |
| 30 to <50 | 1,066 (26.8) | 544 (27.8) |
| <30 | 227 (5.7) | 108 (5.5) |
| Smoking status at baseline, n (%) | ||
| Ex-smoker | 1,721 (43.3) | 690 (35.3) |
| Current smoker | 1,479 (37.2) | 793 (40.6) |
| Never-smoker | 738 (18.6) | 400 (20.5) |
| Missing data | 36 (0.9) | 71 (3.6) |
| Symptoms at baseline, n (%) | ||
| Yes | 3,860 (97.1) | 1,838 (94.1) |
| No | 111 (2.8) | 91 (4.7) |
| Missing | 3 (0.1) | 25 (1.3) |
| mMRC dyspnea scale, mean (SD) | 1.9 (1.0) | 1.8 (1.1) |
| CAT score, mean (SD) | 20.2 (7.6) | 19.5 (7.9) |
Note:
a
Random spirometry assessed without requirement for washout of COPD medication or additional inhalation of short-acting β2-agonist.
Abbreviations: SD, standard deviation; BMI, body mass index; FEV1, forced expiratory volume in 1 second; mMRC, modified Medical Research Council; CAT, COPD Assessment Test.