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. 2016 Jul 21;11:3305–3315. doi: 10.2147/IJN.S106299

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© 2016 Cheng et al. This work is published and licensed by Dove Medical Press Limited

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En face and cross sections of RFPEC in which HS was immunostained in green and cell nuclei in blue.

Notes: (A) Control, (B) low serum, (C) Hep III, and (D) Hep III + HS. (E) Thickness measurements of the glycocalyx when observing only the HS component by binding the 10E4 epitope HS antibody to the glycosaminoglycan under control, low serum, Hep III, and Hep III + HS treatments. HS thickness decreased significantly for all treatments. (F) HS coverage of RFPEC after various treatments. HS coverage decreased significantly after heparinase III treatment and recovered after HS addition. *P<0.05 versus control and **P<0.05 versus Hep III.

Abbreviations: Hep III, heparinase III; HS, heparan sulfate; RFPEC, rat fat pad endothelial cell.