Table 1. Patient characteristics of 151 individuals infected with HCV and /or HIV.
Patients in Group 1, 2 and 3 are considered infected with HIV/HCV for over 15 years before sampling. Group HCVc was mono-infected, HCV chronic. Group HCVr was mono-infected, HCV spontaneously resolved. Group HIV/HCVc was HIV-1+, HCV chronic, HAART naïve. Group HIV/HCVr was HIV-1+, HCV spontaneously resolved, HAART naïve. Group HIVt/HCVc was HIV-1+, HCV chronic, HAART treated. Group HIVt/HCVr was HIV-1+, HCV spontaneously resolved, HAART naïve. ALT, Alanine transaminase; Tbil, Total bilirubin; ALP, Alkaline phosphatase: γ-GT, gamma glutamyl transferase; VL, viral load; IU, international units; HAART, highly active anti retroviral therapy. Values represent mean ± standard deviation.
| HCV mono-infected (Group 1; n = 45) | HIV/HCV co-infected HAART naïve (Group 2; n = 36) | HIV/HCV co-infected HAART received (Group 3: n = 70) | ANOVA p-value (adjusted p)$ | ||||
|---|---|---|---|---|---|---|---|
| Chronic Group HCVc | Resolved Group HCVr | Chronic Group HIV/HCVc | Resolved Group HIV/HCVr | Chronic Group HIVt/HCVc | Resolved Group HIVt/HCVr | ||
| Cases (N) | 24 | 21 | 29 | 7 | 42 | 28 | |
| Gender(M/F) | 10/11 | 11/13 | 14/15 | 4/3 | 27/15 | 13/15 | |
| Age* (y) | 53.7 ±8.8 | 49.5±11.3 | 55.4±9.3 | 53.2±6.4 | 53.03±7.4 | 50.8±5.2 | |
| HIV genotype | - | - | clade B | clade B | clade B | clade B | |
| HCV genotype of chronically infected patients | |||||||
| 1b | 14 | - | 7 | - | 19 | - | |
| 2a | 7 | - | 14 | - | 13 | - | |
| 1b and 2a mix | - | - | - | - | 9 | - | |
| Unknown genotype | 3 | - | 8 | - | 1 | - | |
| ALT*(U/L) | 58.34±54.68 | 25.8±17.9 | 62.1±70.2 | 38.1±43.6 | 53.6±57.6 | 27.9±15.2 | 3.3E-02(2.3E-01) |
| Tbil*(U/L) | 13.12±6.4 | 10.2±4.0 | 13.6±7.1 | 8.4±1.9 | 15.8±9.7 | 11.4±7.1 | 3.4E-02(2.4E-01) |
| ALP* (U/L) | 23.1±6.9 | 20.5±6.6 | 25.6±7.8 | 22.7±5.2 | 29.1±9.5 | 29.4±12.5 | 2.2E-03(1.5E-02)% |
| γ-GT* (U/L) | 57.5±87.2 | 38.2±24.7 | 116.7±210.9 | 27.6±7.1 | 123.9±141.1 | 91.3±98.8 | 7.9E-02(5.5E-01) |
| HCV VL*[log(IU/ml)] | 6±1.3 | - | 6.7±0.6 | - | 6.7±1.2 | - | 1.7E-02(1.2E-01) |
| HIV VL*[log(copies/ml)] | - | - | 3.0±1.1 | 3.5±1.5 | 1.9±0.5 | 2.2±0.9 | 1.3E-07(9.4E-07) |
| CD4+T cell count/ml* | 851±441 | 916±349 | 450±311 | 417±111 | 365±243 | 465±257 | 1.9E-11(1.3E-10)% |
$ Adjusted p value with Bonferroni correction.
%p<0.05