Skip to main content
. 2016 Jul 25;11(7):e0160007. doi: 10.1371/journal.pone.0160007

Table 1. Association between minimal inhibitory concentrations levels (MICs) and gyrA nucleotides substitution and types of mutations in gyrA QRDR.

Patients with gyrA mutations in H. pylori n (%) MIC (μg/mL) gyrA mutations data
Nucleotide change Aminoacid change gyrA mutation and position
35/80 (43.8) 1–32 AAC → ATC Asn → Ile N87I
9/80 (11.3) 2–16 AAC → AAA Asn → Lys N87K
1/80 (1.3) 4 AAC → TAT Asn → Tyr N87Y
23/80 (28.8) 2–32 GAT → GGT Asp → Gly D91G
4/80 (5.0) 1 GAT → AAT Asp → Asn D91N
1/80 (1.3) 2 GAT → TAT Asp →Tyr D91Y
1/80 (1.3) 1 AAC → TAT
GAT → AAT
Asn → Tyr
Asp → Asn
N87Y
D91N
1/80 (1.3) 32 AAC → ATC
GAT → AAT
Asn → Ile
Asp → Asn
N87I
D91G
4/80 (5)* 1–8 AAC
GAT
Asn
Asp
No Mutation
1/80 (1.3)* 0.5 AAC → ATC Asn → Ile N87I

*conflicting results between genotypic and phenotypic resistant