Table 1. Association between minimal inhibitory concentrations levels (MICs) and gyrA nucleotides substitution and types of mutations in gyrA QRDR.
Patients with gyrA mutations in H. pylori n (%) | MIC (μg/mL) | gyrA mutations data | ||
---|---|---|---|---|
Nucleotide change | Aminoacid change | gyrA mutation and position | ||
35/80 (43.8) | 1–32 | AAC → ATC | Asn → Ile | N87I |
9/80 (11.3) | 2–16 | AAC → AAA | Asn → Lys | N87K |
1/80 (1.3) | 4 | AAC → TAT | Asn → Tyr | N87Y |
23/80 (28.8) | 2–32 | GAT → GGT | Asp → Gly | D91G |
4/80 (5.0) | 1 | GAT → AAT | Asp → Asn | D91N |
1/80 (1.3) | 2 | GAT → TAT | Asp →Tyr | D91Y |
1/80 (1.3) | 1 | AAC → TAT GAT → AAT |
Asn → Tyr Asp → Asn |
N87Y D91N |
1/80 (1.3) | 32 | AAC → ATC GAT → AAT |
Asn → Ile Asp → Asn |
N87I D91G |
4/80 (5)* | 1–8 | AAC GAT |
Asn Asp |
No Mutation |
1/80 (1.3)* | 0.5 | AAC → ATC | Asn → Ile | N87I |
*conflicting results between genotypic and phenotypic resistant