Fig 8. Body weight change over time in rats fitted with dentures inoculated with C. albicans biofilm deficient strains.
Equilibrated rats were fitted with dentures, weaned onto gel diet, given antibiotics in the drinking water, and inoculated 3x with 1 x 109 C. albicans DAY185, efg1-/- or bcr1-/-. Rats were weighed bi-weekly for a period of 8 weeks post-inoculation using 3–4 animals per group and data are shown as (A) absolute weights and (B) % weight change (% weight change = weight at time point/weight at week 0 prior to inoculation). Data for individual weight changes per group were analyzed using the Repeated Measures ANOVA. Weight changes between groups at specific time points (experimental vs. control, actual weight or % change) were analyzed by the unpaired Student’s t test. * P < 0.05.