Table 1.
Baseline and Post-Drug-Load Characteristics
| Control-Baseline | Control Post- Load |
VVS Baseline | VVS Post-Load | |
|---|---|---|---|---|
| Systolic BP (mmHg) | ||||
| LNMMA | 117±2 | 123±2 | 121±4 | 120±6 |
| Saline+PE | 115±2 | 120±2 | 118±2 | 122±3 |
| Diastolic BP (mmHg) | ||||
| LNMMA | 62±2 | 69±2 | 63±4 | 68±3 |
| Saline+PE | 65±2 | 70±2 | 63±4 | 65±3 |
| MAP (mmHg) | ||||
| LNMMA | 79±1 | 87±2* | 80±2 | 85±1* |
| Saline+PE | 82±2 | 87±2* | 81±1 | 84±2* |
| HR (bpm) | ||||
| LNMMA | 62±2 | 57±1* | 62±4 | 58±1* |
| Saline+PE | 64±2 | 62±3 | 62±4 | 64±3 |
| CO (L/min) | ||||
| LNMMA | 4.8±0.4 | 4.2±0.4* | 4.9±0.4 | 4.2±0.4* |
| Saline+PE | 5.2±0.4 | 4.6±0.5 | 4.8±0.4 | 4.6±0.5 |
| TPR (mmHg/L/min) | ||||
| LNMMA | 16.4±1.8 | 20.3±2.2* | 16.4±1.0 | 18.4±1.1* |
| Saline+PE | 16.1±1.1 | 18.1±1.5 | 15.8±1.2 | 17.1±1.0 |
| Splanchnic BF (L/min) | ||||
| LNMMA | 1.5±0.2 | 1.2±0.1* | 1.3±0.1 | 1.0±0.1* |
| Saline+PE | 1.2±0.2 | 1.2±0.2 | 1.2±0.1 | 1.2±0.1 |
| Forearm BF (ml%/min) | ||||
| LNMMA | 1.87±0.32 | 1.65±0.33 | 1.81±0.19 | 1.61±0.14 |
| Saline+PE | 2.05±0.33 | 2.10±0.27 | 2.22±0.25 | 2.18±0.12 |
| Calf BF (ml%/min) | ||||
| LNMMA | 2.41±0.57 | 2.33±0.54 | 1.70±0.60 | 1.74±0.58 |
| Saline+PE | 1.93±0.59 | 1.82±0.55 | 1.57±0.32 | 1.54±0.58 |
(Post-Load = following L-NMMA or Saline+PE)
*
=p<0.05 compared to baseline