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. Author manuscript; available in PMC: 2017 Jan 20.
Published in final edited form as: Nature. 2016 Jul 20;535(7612):382–387. doi: 10.1038/nature18325

Extended Data Fig. 10. Brca2-deficient ES cells have higher levels of chromatin-bound MRE11.

Extended Data Fig. 10

(a) Representative image of a Brca2 hypomorph mouse ES (denoted Brca2Y3308X) cell showing MRE11 foci (red) in S-phase (identified by PCNA foci (green). DNA was stained with DAPI (blue). (b) High-throughput microscopy analysis quantifying the overall levels of chromatin-bound MRE11 per individual nucleus in WT and Brca2Y3308X cells treated as indicated (a.u., arbitrary units).