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. 2016 Jul 19;5(4):6. doi: 10.1167/tvst.5.4.6

Figure 1.

Figure 1

Subretinal injection of a single dose (50 K) of hRPC into dexamethasone-treated RCS dystrophic rats significantly preserves vision 3 months after grafting, as assessed using the OKR. (A) At 0.125 C/D there is no effect of transplant or eye. (B) At 0.25 C/D there is a significant interaction between transplantation and eye but no significance at the post hoc level. (C) At the highest spatial frequency (0.5 C/D), transplantation of hRPC significantly improves vision, with the 50 K (cell transplanted) left eyes tracking significantly better than either vehicle-injected (0 K) left eyes or uninjected right eyes. (D) Representative histology images from the left eyes (L) of cell-injected (50 K) and vehicle-injected (0 K) animals 14 weeks after grafting. (E) Quantification of ONL thickness 14 weeks after grafting reveals more ONL in cell-grafted eyes. However, this does not reach statistical significance. Graphs show the mean ± SEM with *P < 0.001 by Bonferroni's comparison. DAPI staining in blue. INL, inner nuclear layer; GCL, ganglion cell layer. Scale bars: 50 μm.