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. 2016 Jul 19;5(4):6. doi: 10.1167/tvst.5.4.6

Figure 2.

Figure 2

In the absence of dexamethasone treatment, subretinal injection of hRPC into RCS dystrophic rats significantly preserves vision and ONL thickness 3 months after grafting. (A) At 0.125 C/D there is a significant effect of dose, with the 10 and 50 K groups tracking more than the 0 K (vehicle) group at the post hoc level. (B) At 0.25 C/D there is a significant effect of eye but not dose. (C) At 0.5 C/D there also was an effect of eye with a dose effect apparent at the post hoc level, where only the eyes injected with 200 K cells tracked significantly better than the uninjected right eyes. (D) Representative histology images from the left eyes (L) of vehicle-injected (0 K) and cell-injected (10–200 K) animals 14 weeks after grafting show clear ONL preservation (arrows) above 50 K. (E) The ONL was significantly preserved in left eyes injected with ≥50K cells (compared to uninjected right eyes). Graphs show the mean ± SEM, with *P < 0.05, **P < 0.01, ***P < 0.001 by Bonferroni's comparison. DAPI staining in blue. Scale bars: 50 μm.